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MALVERN ZETASIZER SLS UPGRADE
MALVERN ZETASIZER SLS SOFTWARE

Integrates with plate-based liquid handling robotics.

All measurements made in situ in the wells.

Industry-standard microwell plates of 96, 384 or 1536 wells.

Measure weight-average molar mass from 1 to 1000 kDa.

Sensitivity for size down to 0.125 mg/mL lysozyme.

Determine particle concentration for particles up to 320 nm in diameter.

Measure hydrodynamic radius from 0.5 nm to 1000 nm.

Screening high-concentration protein solutions for reversible association and viscosity.

Determining protein stability-indicating parameters such as thermal denaturation and colloidal stability.

Quantifying AAV titer for multiple processes.

Assessing aggregation or oligomerization.

The DynaPro Plate Reader provides unparalleled levels of ease-of-use, productivity, reproducibility, and flexibility in order to address additional demanding applications such as:

Viral and non-viral gene vectors like AAV, adenovirus, lentivirus and LNP.Nanoparticle drug delivery vehicles including liposomes and conjugated gold NPs.

Biotherapeutics such as monoclonal antibodies and virus-like particles (VLPs).

This ground-breaking instrument provides rapid optimization of the formulation process for: No liquid handling occurs after dispensing into the plates, to maximize throughput and minimize sample carryover. The DynaPro Plate Reader offers dynamic light scattering (DLS) and static light scattering (SLS) measurements of the size, molecular weight, concentration and interactions of proteins, nanoparticles and other macromolecules in situ in industry-standard microwell plates.

MALVERN ZETASIZER SLS SOFTWARE

The DynaPro Plate Reader is operated by DYNAMICS, our powerful software package for collecting, analyzing, and reporting automated batch dynamic and static light scattering data.ĭYNAMICS is offered with a 21 CFR Part 11 compliant Security Pack option, enabling the use of the DynaPro Plate Reader in a GMP environment. Its automation is particularly valued to screen fractions during process development and then to quantify CQAs in quality control. Even viscosity of concentrated protein solutions can be screened across dozens of formulations in a single plate.įor nanoparticle formulation and process development, including viral vectors, non-viral vectors and nano-drug delivery vehicles, the DynaPro adds particle concentration / physical titer to basic DLS measurements of size and polydispersity. Measure aggregation, aggregate size distributions, changes in solution molecular weight, and propensity for aggregation: indicators of both thermal stability (T onset, T m, T agg) and colloidal stability (A 2/B 22, k D) may be quantified with plate-based DLS and SLS. Even if you need to run just a handful of samples, it's a great productivity booster.įor biotherapeutic development, the DynaPro Plate Reader is a comprehensive solution for stability evaluation. The DynaPro excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments. Revolutionize your performance by replacing your conventional, cuvette-based dynamic light scattering unit with the automated DynaPro ® Plate Reader III.

MALVERN ZETASIZER SLS UPGRADE

High-throughput, automated, dynamic and static light scattering Upgrade to plates Dynamic & Electrophoretic Light Scattering.